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In general.levothyroxine therapy should be instituted at full replacement doses as soon as possible. Delays in diagnosis and institution of therapy may have deleterious effects on the child’s intellectual and physical growth and development.
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Use of oral thyroid hormone drug products is not recommended to treat myxedema coma. administer thyroid hormone products formulated for intravenous administration to treat myxedema coma. myxedema coma is a life-threatening emergency characterized by poor circulation and hypometabolism.and may result in unpredictable absorption of levothyroxine sodium from the gastrointestinal tract.
Thyroid hormone synthesis and secretion is regulated walmart pharmacy prices synthroid the hypothalamic-pituitary-thyroid axis. Thyrotropin-releasing hormone (TRH) released from the hypothalamus stimulates secretion of thyrotropin-stimulating hormone.TSH.from the anterior pituitary. TSH.in turn.is the physiologic stimulus for the synthesis and secretion of thyroid hormones.L-thyroxine (T 4 ) and L-triiodothyronine (T 3 ).by the thyroid gland. Circulating serum T 3 and T 4 levels exert a feedback effect on both TRH and TSH secretion. When serum T 3 and T 4 levels increase.TRH and TSH secretion decrease. When thyroid hormone levels decrease.TRH and TSH secretion increase.
Exercise caution when administering levothyroxine to patients with nontoxic diffuse goiter or nodular thyroid disease in order to prevent precipitation of thyrotoxicosis (see WARNINGS ). If the serum TSH is already suppressed.levothyroxine sodium should not be administered (see CONTRAINDICATIONS ).
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it is unclear as to how synthroid may cause weight gain as most literature suggests that it is weight neutral or unlikely to affect body weight.